Philip Keith Moore
Professor, Department of Pharmacology
Yong Loo Lin School of Medicine
Tel: 6601 1669
Email: dprmpk@nus.edu.sg

What are your present research interests or distinctive viewpoint to your research?

Research in this laboratory centres on the biological roles of hydrogen sulphide (H2S) in the body. Major areas of interest are the potential for H2S donors drugs to alleviate pain and inflammation and to promote a state of healthy ageing.

What do you see as your future research directions?

Molecular targets currently under investigation include the effect of H2S on inflammosome activity which is likely to be an important component of its potential beneficial effect in diseases such as arthritis and atherosclerosis. Other areas of interest include the effect of H2S on neurodegenerative conditions such as Parkinson’s and Alzheimer’s. Numerous pharmacological and molecular biological techiques are available in collaboration with multiple interested co-workers.

Does your laboratory have a particularly strong research expertise?

Future work will likely centre on the chemical synthesis and biological evaluation of novel H2S donors again in these various disease states as well as their preclinical evaluation in terms of possible druggability.

Recent Publications

1. Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity. Cao X, Zhang W, Moore PK, Bian J.Int J Mol Sci. 2019 Jan 14;20(2). pii: E313. doi: 10.3390/ijms20020313. Review. PMID:30646560
2. Hydrogen sulfide inhibits ATP-induced neuroinflammation and Aβ1-42 synthesis by suppressing the activation of STAT3 and cathepsin S. Cao L, Cao X, Zhou Y, Nagpure BV, Wu ZY, Hu LF, Yang Y, Sethi G, Moore PK, Bian JS. Brain Behav Immun. 2018 Oct;73:603-614. doi: 10.1016/j.bbi.2018.07.005. Epub 2018 Jul 5. PMID: 29981830
3. Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. Wu W, Qin M, Jia W, Huang Z, Li Z, Yang D, Huang M, Xiao C, Long F, Mao J, Moore PK, Liu X, Zhu YZ. Cell Mol Immunol. 2018 May 29. doi: 10.1038/s41423-018-0037-8. [Epub ahead of print] PMID: 29844591
4. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? Cao X, Ding L, Xie ZZ, Yang Y, Whiteman M, Moore PK, Bian JS. Antioxid Redox Signal. 2019 Jul 1;31(1):1-38. doi: 10.1089/ars.2017.7058. Epub 2018 Jun 29. PMID: 29790379
5. Garlic and Gaseous Mediators. Rose P, Moore PK, Zhu YZ. Trends Pharmacol Sci. 2018 Jul;39(7):624-634. doi: 10.1016/j.tips.2018.03.009. Epub 2018 Apr 26. Review. PMID: 29706261