What are your present research interests or distinctive viewpoint to your research?

Understanding the molecular mechanisms of cell injury and death in human disease and in response to toxins.

• Mechanisms of neurodegeneration in humans
• Elucidation of the role of iron in the development of human disease
• Antioxidants and pro-oxidants in the human diet in relation to health and disease
• Mechanisms of ageing in the nematode Caenorhabditis elegans and in human populations

What do you see as your future research directions?

To understand ageing and age-related diseases and to develop novel antioxidant-based therapies for the major neurodegenerative diseases especially the dementias.

Does your laboratory have a particularly strong research expertise?

Expertise in all areas of free radical/antioxidant biology and in the measurement and characterization of oxidative damage.

Recent Publications

1. Butterfield DA and Halliwell B. (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nature Reviews Neuroscience 20, 148-160.
2. Tang RMY, Cheah IKM, Yew TSK, Halliwell B. (2018) Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues. Sci Rep. 8, 1601.
3. Cheah IK, Tang RM, Yew TS, Lim KH, Halliwell B. (2017) Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. Antioxid Redox Signal 26, 193-206
4. Cheah IK, Feng L, Tang RM, Lim KH, Halliwell B. (2016) Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? Biochem Biophys Res Commun. 478, 162-7.
5. Halliwell B & Gutteridge JMC (2015) Free Radicals in Biology and Medicine. Clarendon Press, Oxford (5th edition), UK.