Chow Jeng Yeong
Research Assistant Professor
Department of Biochemistry, Yong Loo Lin School of Medicine
Principal Investigator, NUS SynCTI
Tel: +65 6601 2449
Email: bchcjy@nus.edu.sg

What are your present research interests?

My current research interests involve the engineering of enzymes for various industrial applications.

Do you have a distinctive viewpoint to your research?

Protein engineering has the potential to unlock interesting biochemical reactions that are usually not found in nature. With the ability to imitate natural evolution of enzymes in a test-tube, we hope to identify variants that has potential to be used in translational research.

What do you see as your future research directions?

With the rapid advancement in automation and robotics, we hope to integrate many of these systems into our biofoundry to facilitate the screening process with higher efficiency and efficacy.

Does your laboratory have a particularly strong research expertise?

Our lab has the capability to design high-throughput assays to facilitate the screening of enzymes with interesting activities or biophysical properties.

Recent Publications

1. Blank PN, Pemberton TA, Chow JY, Poulter CD, Christianson DW. (2018). Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene. Biochemistry. 57, 6326-6335.
2. Chow JY, Tian BX, Ramamoorthy G, Hillerich BS, Seidel RD, Almo SC, Jacobson MP, Poulter CD (2015). Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus. Proc Natl Acad Sci U S A. 112: 5661-5666.
3. Go MK, Wongsantichon J, Cheung VW, Chow JY, Robinson RC, Yew WS. (2015). Synthetic polyketide enzymology: platform for biosynthesis of antimicrobial polyketides. ACS Catal. 5: 4033-4042.